• Andrew Webb

An inflammatory messenger: Immunogenic exosome cargo in rheumatoid arthritis

Our understanding of the role exosomes play in disease progression continues to develop and highlights their research potential to not only provide new insights into disease mechanisms, but their enormous diagnostic potential as well. Exosomes are small membrane encapsulated vesicles, typically 30-100nm in diameter and are actively secreted by most cell types studied. They contain DNA, RNA, protein and lipid cargo and have been observed to induce effects and changes in target cells when taken up.

Whilst the exosomes have in particular been studied in the context of cancer progression and biomarkers, recently it has emerged that during autoinflammatory conditions, they can potentially play a pathogenic role in disease progression.

Here, Foers et al use IonOpticks Aurora Series columns to comprehensively characterise synovial fluid (SF) exosomes which demonstrated their potential contributions to inflammatory pathways in Rheumatoid Arthritis. This work has led to a greater understanding of the immunomodulatory properties of synovial exosomes and how they may modulate the course of disease.

Proteomic analysis of extracellular vesicles reveals an immunogenic cargo in rheumatoid arthritis synovial fluid.

Clinical & Translational Immunology. 2020 07 Nov. doi: https://doi.org/10.1002/cti2.1185

Foers AD, Dagley LF, Chatfield S, Webb AI, Cheng L, Hill AF, Wicks IP, Pang KC